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Xenical
Orlistat
Xenical 120mg, 60mg
ACTIVE INGREDIENT: ORLISTAT
xenical pill

Xenical is a powerful weight loss and weight control drug. The principle of action is based on the fact that the active ingredient Orlistat prevents the division of fats into small fractions and prevents them from being absorbed in the body. It happens due to the action of enzymes produced by the pancreas. The active ingredient Orlistat blocks the production of these enzymes by stopping breaking down and assimilating fats. As a result, most of the fats that enter the body are excreted with feces and urine. In other words, Xenical creates a deficit of incoming fats, and the body begins to use the previously accumulated fats to maintain the vital functions of the body. While taking the drug, it is recommended to abandon the usual dishes and follow a diet to control the intake of calories. Thus, the process of consumption of previously accumulated fats by the body will begin much faster.

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How does Xenical work and what happens physiologically inside a person?

Xenical is used to treat metabolic syndrome, obesity, and imbalance of high and low-density lipoproteins. The composition contains an active ingredient Orlistat. Xenical refers to the group that blocks enzymes in the digestive tract called lipases. The capsules consist of gelatin with a dosage of 60mg and 120 mg.

The drug interferes with the breakdown of triglycerides by acting on digestive enzymes, thereby reducing their absorption into the bloodstream. Prolonged use of Xenical helps to reduce body weight. The mechanism of action consists of forming a chemical bond with the active sites of enzymes, making them inactive. Thus, the fats entering the body cannot be absorbed; therefore, the amount of calories consumed is reduced.

How is Xenical absorbed and then excreted by the body?

When taking the drug, the absorption of fats in the intestine is deficient. Metabolism occurs in the intestinal walls with the formation of inactive metabolites. Xenical is excreted in the feces up to 98%, and the kidneys are excreted in less than 2%. 2-3 days after stopping the intake of orlistat, the amount of fat in the feces returns to normal.

Recommendations for use and dosage

Doctors prescribe the drug, and the dose is selected individually. Taking medicine with meals, or no later than 1 hour.

Orlistat is taken in a dosage of 60 mg per meal, together with the main meal containing fats, or no later than 1 hour. The maximum daily dose of Xenical is 180 mg per day. It is allowed to skip taking the drug if the meal did not contain fats or was skipped. The duration of drug intake is no more than half a year.

Overdose

There is no data on drug overdose. Even the dosage of orlistat 800 mg per day at once and 400 mg 3 times a day did not cause significant side effects.

Indications for the treatment of overweight

• Decrease in body weight in obese patients in conjunction with a hypocaloric diet;
• Prevention of weight gain after its initial loss;
• The drug is taken if the BMI is more than 30 kg / m2, or more than 27 kg / m2, but with concomitant pathology: dyslipidemia, diabetes mellitus, arterial hypertension.

BMI of 30 or more means obesity
overweight
If your BMI is between 25 and 29.9, you are overweight
obesity
If your BMI level varies from 18.5 to 24.9 then this is considered normal.
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Special instructions when taking the drug

Treatment with Xenical does not exclude the use of a low-calorie diet. If the amount of fat exceeds 30% of the total daily calorie intake, the risk of side effects increases significantly.

It is necessary to increase the consumption of fruits and vegetables. The daily calorie intake of carbohydrates, fats, and proteins are divided into three main meals.

Before prescribing Xenical, doctors rule out thyroid pathologies, such as hypothyroidism, leading to obesity and other organic pathology.

Orlistat affects the absorption of fat-soluble vitamins. Therefore, patients need to use multivitamin complexes of fat-soluble vitamins in addition.

The intake of fat-soluble vitamins should be 2 hours before taking the drug or 2 hours after. The best time to take is before bedtime. Since orlistat affects the absorption of Vitamin K., it is not compatible with taking warfarin and other indirect anticoagulants.

With increasing doses above 360 mg per day, a significant effect of the drug has not been observed.

When taken together with cyclosporine, constant monitoring of cyclosporine in the blood is necessary.

Different studies show that the concentration of oxalates in the urine increases in some patients.

Patients may abuse the drug, especially those suffering from mental disorders such as bulimia and anorexia.

With prolonged and systematic use, it improves diabetes mellitus, which may be necessary to reduce the doses of hypoglycemic drugs.

After 12 weeks, it is necessary to control weight loss. If it is less than 5%, it is recommended to consult a doctor and stop taking the drug. The duration of treatment should not exceed two years.

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In what cases is Xenical contraindicated?

• Disruption of the gallbladder;
• Individual intolerance;
• Children up to age 18;
• Pregnancy:
• Feeding period;
• Nephrolithiasis (in particular the oxalate composition of stones)
• Hyperoxaluria
• Gout

Can Xenical (Orlistat) be taken during pregnancy or lactation?

The use of Xenical during pregnancy and lactation is contraindicated due to the lack of reliable studies.

What are the possible side effects of Xenical?

• Steatorrhea;
• Increased bowel movements;
• Gassing with emissions;
• Fecal incontinence;
• Oily discharge from the rectum;
• Imperative urge to defecate;
• Bloating;
• Abdominal pain;
• Headaches;
• Urinary tract infections;
• Violation of the menstrual cycle;
• Feeling of anxiety;
• Rash, itching, and other allergic reactions;
• Increase in liver enzymes: transaminases, alkaline phosphatase;

Interaction with other drugs

The combined use of orlistat and cyclosporin reduces the level of cyclosporine in the plasma. In order to reduce drug interactions, it is necessary to take cyclosporine 2 hours before taking Xenical or after 2 hours.

Since orlistat can reduce the absorption of vitamin K, simultaneous use with indirect anticoagulants is not recommended, or the drug should be used under the control of coagulation tests and INR.

Orlistat affects pravastatin and increases its concentration and lipid-lowering effect.

As mentioned earlier, orlistat reduces the absorption of fat-soluble vitamin K and other vitamins A, D, E. Therefore, they must be compensated by using a multivitamin complex 2 hours before taking orlistat or 2 hours after taking it.

It is necessary to adjust the doses of lipid-lowering drugs for diabetes, as the drug battling metabolic syndrome.

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Obesity as the main problem

According to statistics, in 2021, 16% of the world's population is obese. This problem is growing at an incredible rate. For example, from 1975-2021, the number of people officially diagnosed with obesity has tripled and is growing every year, increasing its pace. The main reason for the development of this pathology is energy imbalance. Energy imbalance is a condition in which the daily calorie intake exceeds the body's energy expenditure.

The main reasons for this:

• Increase in foods high in fat;
• Sedentary lifestyle of the population.

Why is obesity progressing so rapidly?

Every overweight person asks this question. Now we will try to answer this question.

So, the development of obesity contributes to:

1) Completely confused diet, namely eating at night and before bedtime, overeating, unhealthy diet, excessive amounts of fat, fast carbohydrates and salt in food, and the use of alcohol, soda, various seasonings, and spices with flavor enhancers.
2) Lack of physical activity, ranging from a sedentary lifestyle at work, as well as a complete cessation of sports.
3) It is also worth mentioning the progression of medical pathology, which entails metabolic syndrome in general and obesity as a consequence. These can be diseases of the endocrine system: hypothyroidism, hypogonadism, type 2 diabetes mellitus, diseases of the nervous system: brain tumors responsible for eating behavior, and a significant increase in oncology in the world.
4) Frequent use of medications such as hormones, antidepressants, which also contribute to obesity.
5) Constant stress and insomnia.
6) Physiological conditions of women: pregnancy, lactation, menopause.

I was told that I have a high BMI. What does it mean?

BMI (body mass index) is the ratio of a person's body weight to his height.

How to calculate:

Body weight in kilograms divided by the square of height in meters (kg / m2).

The norm is from 18.5 to 25 kg / m2. Above 25 kg / m2 and up to 30 kg / m2 is considered pre-obesity. In other words, this is the initial form of obesity, but without the main symptoms. This condition is well corrected by following a diet and performing elementary physical activity.

I am obese. What should I wait for?

There are 3 stages of overweight.

Stage 1: BMI 30-34.9 kg / m2. The first signs of the disease appear: increased sweating, swelling in the legs, shortness of breath with moderate physical exertion. This stage is often taken as a cosmetic defect, but not for stage 1 of the disease. However, the treatment at this stage is still easier.

Stage 2: Characterized by a BMI of 35-39.9 kg / m2. Significant fat deposits are visible, physical activity decreases, and efficiency is lost. This grade progresses very quickly to Grade 3.

Stage 3: Characterized by a BMI of 40 kg / m2 and entails swelling, headaches, disturbances in the work of the heart, shortness of breath even in a calm state. Such a person needs care since he is not able to serve the physiological needs independently.

What diseases does obesity entail?

Obesity is the problem of the 21st century. Even the initial stages do not pass without a trace inside us. The body works in eternal exhaustion. And then, along the chain, such terrible diseases begin to appear, which lead to disability:
The pancreas disease - cells do not perceive the hormone insulin, which transfers glucose into cells. Therefore, all glucose accumulates and converts to fat.
Heart diseases - ischemic heart disease, heart attacks, arterial hypertension, arrhythmias and cardiac conduction disturbances, cardiosclerosis.
Vascular diseases - atherosclerosis, stroke, thrombosis, thromboembolism.
Diseases of the liver and biliary tract - fatty degeneration, hepatosis, cirrhosis, cholestasis, cholelithiasis.
Diseases of the musculoskeletal system - damage to muscles, joints, ligaments, arthritis, arthrosis.
Skin diseases - eczema, allergic reactions, excessive sweating, diaper rash.
Female diseases - polycystic ovary disease, leading to infertility.
Male diseases - sexual dysfunctions, breast, and colon cancer, decreased testosterone, and libido.
Respiratory tract diseases - obstructive sleep apnea syndrome, Pickwick's syndrome, fat deposits on the neck lead to difficulty breathing, night snoring.
Pickwickian syndrome is a disease that leads to oxygen starvation, increased sleepiness due to respiratory failure. The risk of sudden death increases even more.
Obesity has progressed, and now it can easily be met among children. Obese children are at increased risk of developing obesity in adulthood, as well as increasing disability. They have an increased likelihood of fractures, a tendency to hypertension and cardiovascular disease, shortness of breath, and psychological problems.

Is it possible to lose weight without harm to health through the practice of alternative medicine?

The most well-known alternative medicine treatments for obesity are: ⦁ Use of high temperature –thermopuncture;
⦁ The use of low temperature - cryoreflexotherapy;
⦁ Point massage - acupressure;
⦁ Using needles made of special alloys, for example, silver - acupuncture.
Usually, this type of treatment has an effect, but it is short-lived or mild. The primary treatment that helps to cope with this pathology is discipline. Furthermore, it starts with a healthy lifestyle, exercises, and a low-calorie diet. The drug Xenical can help you to lose or control weight but do not pin all your hopes on it and at the same time eat whatever. The drug will only work in conjunction with diet and exercise.

Brief conclusion

Children should be taught the proper habits from childhood, such as eating fruits and vegetables and playing sports.

The prevention of the disease includes the correct diet and the restriction of easily digestible carbohydrates. It is necessary to establish a diet, give up snacks before bed and at night, and do not abuse fast food.

Every person needs sports, be it a child or an older person with many diseases. The only thing is that the load on the body should be dosed. Exercise daily for 10 minutes of morning exercises and go for walks. Most people can afford this.

First of all, obesity treatment is a struggle with oneself, a manifestation of willpower and character, the ability to limit oneself where temptation is great. Food is a resource for energy but not a resource for pleasure. Obesity treatment is a lifelong process, like all chronic diseases.

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